899 Population coverage of HLA-A*02:01, *02:05, *02:06 across selected cancer types in the United States

Background GSK is investigating an autologous TCR T-cell therapy for solid tumors that recognizes the cancer testis antigen, NY-ESO-1, presented on cell surface by specific HLA-A*02 sub-types. The aim of this study was to estimate number patients in US 2020 with genotype subtypes HLA-A*02:01, 02:05, 02:06 across selected types (invasive lung, ovarian, gastric, esophageal, invasive and in-situ bladder multiple myeloma), accounting racial variation. Methods This carried out three parts utilizing national datasets.1. prevalence each type estimated race rates from Surveillance, Epidemiology, End Results (SEER) 1975–2018 data. 1 2. population coverage subtype (%) 2020, Hardy Weinberg Principles allele frequencies extracted frequency net database (US National Marrow Donor Program (NMDP) only). 2 3. expression subtype, calculated using Census (2019) 3 For purpose analyses, single estimates were used. Race categorized as ‘White’, ‘Black’, ‘Asian/Pacific Islander’, ‘Native American’ ‘Other’. Hispanic included a proportion category, where appropriate. Limitations include seven assumptions underlying Hardy-Weinberg equilibrium, which met, assumption NMDP, SEER data are reflective population. Predictive prognostic clinical characteristics including histological not accounted analysis. Across types, most prevalent category White, reflecting distribution (table 1). Of these myeloma gastric represented lowest White highest Black patients. HLA sub-type table below. overall who *02:05 or *02:06 positive be between 41.7% (multiple myeloma) 45.8% bladder) variations interest. Abstract 899 Table Proportion *02:05, Conclusions similar cancers, variation US. Racial important consideration when estimating size eligible populations therapies requiring histocompatibility. Acknowledgements Funding GlaxoSmithKline References Howlader N, Noone AM, Krapcho M, Miller D, Brest A, Yu Ruhl J, Tatalovich Z, Mariotto Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). Cancer Statistics Review, 1975–2018, Institute. Bethesda, MD, [https://seer.cancer.gov/csr/1975_2018/], based November submission, posted web site, April 2021 (Accessed July 2021). Gonzalez-Galarza FF, McCabe Santos Jones Takeshita LY, Ortega-Rivera ND, Del Cid-Pavon GM, Ramsbottom K, Ghattaoraya GS, Alfirevic Middleton AR. Allele (AFND) update: gold-standard classification, open access new query tools. Nucleic Acids Res 2020; 48 :D783–8. U S Bureau (2011). ACS demographic housing estimates. [https://data.census.gov/cedsci/table?q=United%20States&g=0100000US&tid=ACSDP1Y2017.DP05&vintage=2017&layer=state&cid=DP05_0001E]